Key Insights

The Knock Out Mouse Model market, valued at $1.37 billion in 2025, is projected to experience robust growth, exhibiting a compound annual growth rate (CAGR) of 5.20% from 2025 to 2033. This expansion is driven by several key factors. The increasing prevalence of chronic diseases like cancer and neurological disorders fuels the demand for preclinical research models, with knockout mice playing a crucial role in drug discovery and development. Advancements in gene editing technologies, such as CRISPR-Cas9, are further accelerating market growth by enabling the creation of more precise and efficient knockout mouse models. The rising adoption of personalized medicine also contributes, as researchers utilize these models to study individual genetic variations and tailor treatments accordingly. The market is segmented by application (oncology, neurology, cardiovascular, and other applications), end-user (clinical research organizations, pharma & biotechnology companies, and others), and type (constitutive, conditional, and protein function knockout mice). The North American market currently holds a significant share, driven by robust research infrastructure and funding, followed by Europe and the Asia-Pacific region.

However, the market faces some restraints. The high cost associated with generating and maintaining knockout mouse models can limit accessibility for smaller research institutions. Ethical considerations surrounding animal research also remain a significant concern, requiring stringent regulatory compliance and potentially influencing market growth. Furthermore, the emergence of alternative research methods, such as induced pluripotent stem cells (iPSCs), presents competitive challenges. Despite these challenges, the continued advancement of genetic engineering techniques and the growing need for effective drug development strategies are expected to propel the market forward, particularly in applications like oncology and neurology where the efficacy of targeted therapies relies heavily on preclinical validation using sophisticated models such as knockout mice. The increasing investment in research and development by pharmaceutical and biotechnology companies, coupled with the growing adoption of contract research organizations (CROs), will further contribute to the market's expansion during the forecast period.

This comprehensive report provides an in-depth analysis of the Knock Out Mouse Model market, offering valuable insights for stakeholders across the pharmaceutical, biotechnology, and research sectors. The report covers the period 2019-2033, with a focus on the forecast period 2025-2033 and a base year of 2025. The analysis encompasses market size, segmentation, key players, growth drivers, challenges, and emerging opportunities, providing a 360-degree view of this dynamic market expected to reach xx Million by 2033.

Knock Out Mouse Model Market Market Concentration & Innovation

The Knock Out Mouse Model market exhibits a moderately concentrated landscape, with several major players holding significant market share. Charles River Laboratories, Taconic Biosciences Inc., The Jackson Laboratory, and Envigo are among the leading companies, collectively accounting for an estimated xx% of the global market in 2025. Market share dynamics are influenced by factors such as R&D capabilities, technological innovation, and global reach.

Innovation is a key driver in this market, fueled by advancements in gene editing technologies (e.g., CRISPR-Cas9), the increasing demand for disease models, and the growing adoption of personalized medicine. Regulatory frameworks, particularly those related to animal welfare and research ethics, play a crucial role in shaping market dynamics. The presence of substitute technologies (e.g., in silico models) presents a competitive challenge, though the accuracy and complexity of knock out mouse models remain unparalleled for many research applications.

Mergers and acquisitions (M&A) are common, reflecting the consolidation trend within the industry. Significant deals, though exact values are confidential in many cases, involve smaller companies being acquired by larger players to bolster their portfolios and expand their market reach. In the past five years, M&A activity has resulted in an estimated xx Million in deal value. End-user trends, particularly the rising demand from pharmaceutical and biotechnology companies for preclinical research, are driving growth.

Knock Out Mouse Model Market Industry Trends & Insights

The Knock Out Mouse Model market is projected to experience robust growth throughout the forecast period (2025-2033), driven by the increasing prevalence of chronic diseases requiring advanced preclinical models, the accelerating pace of drug discovery and development, and the growing adoption of personalized medicine approaches. The market is expected to exhibit a CAGR of xx% during this period. This growth is further fueled by technological advancements in gene editing techniques, enabling the creation of more precise and sophisticated knockout mouse models. Market penetration of knockout mouse models in various research areas, such as oncology and neurology, is increasing steadily as researchers recognize the value of these models for replicating human diseases and evaluating potential drug targets. However, challenges such as high cost, lengthy development timelines, and ethical concerns related to animal research act as potential restraints on market expansion. The increasing adoption of advanced imaging techniques and bioinformatics tools for analyzing knockout mouse model data contributes to the higher market growth. The competitive landscape is characterized by both established players and emerging companies, leading to continuous innovation and new product launches.

Dominant Markets & Segments in Knock Out Mouse Model Market

Dominant Regions/Countries: North America and Europe currently dominate the Knock Out Mouse Model market, owing to strong research infrastructure, high healthcare expenditure, and a significant presence of pharmaceutical and biotechnology companies. However, the Asia-Pacific region is expected to experience significant growth in the coming years, driven by factors such as increasing healthcare spending and growing adoption of advanced research techniques.

Dominant Application Segment: Oncology is the leading application segment, driven by the high prevalence of various types of cancer and the need for effective preclinical models to evaluate new therapies.

Dominant End-User Segment: Pharma & Biotechnology Companies are the dominant end-users, owing to their extensive use of knockout mouse models in drug discovery and development.

Dominant Type Segment: Conditional Knockout Mouse models are becoming increasingly popular due to their ability to precisely control gene expression.

• Key Drivers for Dominant Segments:
  • Oncology: High cancer prevalence, need for effective therapies, and personalized medicine.
  • Pharma & Biotech: Extensive use in drug development, high R&D budgets.
  • Conditional Knockout Mice: Flexibility in controlling gene expression for improved research accuracy.

Knock Out Mouse Model Market Product Developments

Recent years have witnessed significant advancements in Knock Out Mouse Model technology. The development of gene editing technologies, such as CRISPR-Cas9, has enabled the creation of more precise and efficient knockout mouse models, resulting in faster and more cost-effective research. This has expanded the applications of these models beyond traditional research and into areas such as personalized medicine and drug discovery. The market sees competition among providers around speed of model creation, precision of gene editing, and the range of genetic modifications available, leading to improved model accuracy and increased data reliability for researchers.

Report Scope & Segmentation Analysis

This report segments the Knock Out Mouse Model market based on Application (Oncology, Neurology, Cardiovascular, Other Applications), End-User (Clinical Research Organizations, Pharma & Biotechnology Companies, Others), and Type (Constitutive Knockout Mouse, Conditional Knockout Mouse, Protein Function Knockout Mouse). Each segment’s market size, growth projections, and competitive dynamics are analyzed in detail. For example, the Oncology segment is experiencing rapid growth due to the increasing incidence of cancer, while the Conditional Knockout Mouse segment is gaining popularity due to its enhanced research capabilities. Similarly, Pharma & Biotechnology companies are the major end-users, driving market demand. Growth projections for each segment vary, based on factors unique to the segment.

Key Drivers of Knock Out Mouse Model Market Growth

The Knock Out Mouse Model market is driven by several factors, including: the increasing prevalence of chronic diseases, the growing demand for preclinical models for drug discovery and development, the advancements in gene-editing technologies, the rising adoption of personalized medicine approaches, and increased funding for research and development. Stringent regulatory frameworks, although posing some initial challenges, also foster innovation and improved research practices within the sector.

Challenges in the Knock Out Mouse Model Market Sector

The Knock Out Mouse Model market faces several challenges, including high costs associated with the generation and maintenance of mouse models, ethical considerations surrounding animal research, stringent regulatory requirements, and the potential for variability between individual models. Furthermore, the emergence of alternative technologies, such as in silico modeling, presents competitive pressure on this market. The supply chain, especially with regards to the availability of specific genetic strains and reagents, also represents a logistical challenge.

Emerging Opportunities in Knock Out Mouse Model Market

Emerging opportunities exist in the development of more sophisticated and customized knockout mouse models, the integration of advanced imaging and data analysis techniques, and the exploration of new therapeutic areas. The increasing use of humanized mouse models, which more closely mimic human physiology, presents significant potential. Focus on faster generation times and reduced costs will also generate opportunities for market players.

Leading Players in the Knock Out Mouse Model Market Market

• Charles River Laboratories
• Ozgene Pty Ltd
• The Jackson Laboratory
• Ingenious Targeting Laboratory
• Taconic Biosciences Inc
• Envigo
• Cyagen Biosciences
• genOway
• Ximbio
• Trans Genic Inc

Key Developments in Knock Out Mouse Model Market Industry

• September 2023: Biocytogen Pharmaceuticals (Beijing) Co., Ltd. announced the RenMice series, featuring fully human antibody mice and TCR mice. This significantly expands the capabilities of humanized models for antibody discovery.
• August 2023: GemPharmatech launched NeoMab, a fully antibody gene humanized mouse model, addressing the rising demand for therapeutic antibody development. This new model is expected to accelerate the drug discovery process for many therapeutic areas.

Strategic Outlook for Knock Out Mouse Model Market Market

The Knock Out Mouse Model market is poised for significant growth, driven by ongoing advancements in gene editing technologies, the increasing demand for preclinical models, and the rising prevalence of chronic diseases. Continued innovation in model generation and data analysis, as well as strategic partnerships among companies and research institutions, will shape future market opportunities. The market's future hinges on adapting to evolving regulatory frameworks and responding to the ethical considerations surrounding animal research while maintaining its crucial role in advancing medical and biological understanding.

Knock Out Mouse Model Market Segmentation

• 1. Type
  • 1.1. Constitutive Knockout Mouse
  • 1.2. Conditional Knockout Mouse
  • 1.3. Protein Function Knockout Mouse
• 2. Application
  • 2.1. Oncology
  • 2.2. Neurology
  • 2.3. Cardiovascular
  • 2.4. Other Applications
• 3. End-User
  • 3.1. Clinical Research Organizations
  • 3.2. Pharma & Biotechnology Companies
  • 3.3. Others

Knock Out Mouse Model Market Segmentation By Geography

• 1. North America
  • 1.1. United States
  • 1.2. Canada
  • 1.3. Mexico
• 2. Europe
  • 2.1. Germany
  • 2.2. United Kingdom
  • 2.3. France
  • 2.4. Italy
  • 2.5. Spain
  • 2.6. Rest of Europe
• 3. Asia Pacific
  • 3.1. China
  • 3.2. Japan
  • 3.3. India
  • 3.4. Australia
  • 3.5. South Korea
  • 3.6. Rest of Asia Pacific
• 4. Middle East and Africa
  • 4.1. GCC
  • 4.2. South Africa
  • 4.3. Rest of Middle East and Africa
• 5. South America
  • 5.1. Brazil
  • 5.2. Argentina
  • 5.3. Rest of South America